Study could spur wider use of prenatal gene tests

A new study sets the stage for wider use of gene testing in early pregnancy. Scanning the genes of a fetus reveals far more about potential health risks than current prenatal testing does, say researchers who compared both methods in thousands of pregnancies nationwide.

A surprisingly high number — 6 percent — of certain fetuses declared normal by conventional testing were found to have genetic abnormalities by gene scans, the study found. The gene flaws can cause anything from minor defects such as a club foot to more serious ones such as mental retardation, heart problems and fatal diseases.

"This isn't done just so people can terminate pregnancies," because many choose to continue them even if a problem is found, said Dr. Ronald Wapner, reproductive genetics chief at Columbia University Medical Center in New York. "We're better able to give lots and lots of women more information about what's causing the problem and what the prognosis is and what special care their child might need."

He led the federally funded study, published in Thursday's New England Journal of Medicine.

A second study in the journal found that gene testing could reveal the cause of most stillbirths, many of which remain a mystery now. That gives key information to couples agonizing over whether to try again.

The prenatal study of 4,400 women has long been awaited in the field, and could make gene testing a standard of care in cases where initial screening with an ultrasound exam suggests a structural defect in how the baby is developing, said Dr. Susan Klugman, director of reproductive genetics at New York's Montefiore Medical Center, which enrolled 300 women into the study.

"We can never guarantee the perfect baby but if they want everything done, this is a test that can tell a lot more," she said.

Many pregnant women are offered screening with an ultrasound exam or a blood test that can flag some common abnormalities such as Down syndrome, but these are not conclusive.

The next step is diagnostic testing on cells from the fetus obtained through amniocentesis, which is like a needle biopsy through the belly, or chorionic villus sampling, which snips a bit of the placenta. Doctors look at the sample under a microscope for breaks or extra copies of chromosomes that cause a dozen or so abnormalities.

The new study compared this eyeball method to scanning with gene chips that can spot hundreds of abnormalities and far smaller defects than what can be seen with a microscope. This costs $1,200 to $1,800 versus $600 to $1,000 for the visual exam.

In the study, both methods were used on fetal samples from 4,400 women around the country. Half of the moms were at higher risk because they were over 35. One-fifth had screening tests suggesting Down syndrome. One-fourth had ultrasounds suggesting structural abnormalities. Others sought screening for other reasons.

"Some did it for anxiety — they just wanted more information about their child," Wapner said.

Of women whose ultrasounds showed a possible structural defect but whose fetuses were called normal by the visual chromosome exam, gene testing found problems in 6 percent — one out of 17.

"That's a lot. That's huge," Klugman said.

Gene tests also found abnormalities in nearly 2 percent of cases where the mom was older or ultrasounds suggested a problem other than a structural defect.

Dr. Lorraine Dugoff, a University of Pennsylvania high-risk pregnancy specialist, wrote in an editorial in the journal that gene testing should become the standard of care when a structural problem is suggested by ultrasound. But its value may be incremental in other cases and offset by the 1.5 percent of cases where a gene abnormality of unknown significance is found.

In those cases, "a lot of couples might not be happy that they ordered that test" because it can't give a clear answer, she said.

Ana Zeletz, a former pediatric nurse from Hoboken, N.J., had one of those results during the study. An ultrasound suggested possible Down syndrome; gene testing ruled that out but showed an abnormality that could indicate kidney problems — or nothing.

"They give you this list of all the things that could possibly be wrong," Zeletz said. Her daughter, Jillian, now 2, had some urinary and kidney abnormalities that seem to have resolved, and has low muscle tone that caused her to start walking later than usual.

"I am very glad about it," she said of the testing, because she knows to watch her daughter for possible complications like gout. Without the testing, "we wouldn't know anything, we wouldn't know to watch for things that might come up," she said.

The other study involved 532 stillbirths — deaths of a fetus in the womb before delivery. Gene testing revealed the cause in 87 percent of cases versus 70 percent of cases analyzed by the visual chromosome inspection method. It also gave more information on specific genetic abnormalities that couples could use to estimate the odds that future pregnancies would bring those risks.

The study was led by Dr. Uma Reddy of the National Institute of Child Health and Human Development.

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Medical journal: http://www.nejm.org

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Marilynn Marchione can be followed at http://twitter.com/MMarchioneAP

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Guatemala Could Deport McAfee to Belize

Software anti virus pioneer John McAfee is in the process of being deported to Belize after he was arrested in Guatemala for entering the country illegally, his attorney told ABC News early Thursday.

ABC News has learned that John McAfee is scheduled to be deported to Belize later this morning. But a judge could stay the ruling if it is determined McAfee's life is threatened by being in Belizean custody, as McAfee has claimed over the past several weeks.

Just hours before McAfee's arrest, he told ABC News in an exclusive interview Wednesday he would be seeking asylum in Guatemala. McAfee was arrested by the Central American country's immigration police and not the national police, said his attorney, who was confident his client would be released within hours.

"Thank God I am in a place where there is some sanity," said McAfee, 67, before his arrest. "I chose Guatemala carefully."

McAfee said that in Guatemala, the locals aren't surprised when he says the Belizean government is out to kill him.
"Instead of going, 'You're crazy,' they go, 'Yeah, of course they are,'" he said. "It's like, finally, I understand people who understand the system here."

But McAfee added he has not ruled out moving back to the United States, where he made his fortune as the inventor of anti-virus software, and that despite losing much of his fortune he still has more money than he could ever spend.
In his interview with ABC News, a jittery, animated but candid McAfee called the media's representation of him a "nightmare that is about to explode," and said he's prepared to prove his sanity.

Johan Ordonez/AFP/Getty Images

Software Founder Breaks Silence: McAfee Speaks on Murder Allegations Watch Video

John McAfee Interview: Software Mogul Leaves Belize Watch Video

John McAfee Interview: Software Millionaire on the Run Watch Video

McAfee has been on the run from police in Belize since the Nov. 10 murder of his neighbor, fellow American expatriate Greg Faull.

During his three-week journey, said McAfee, he disguised himself as handicapped, dyed his hair seven times and hid in many different places during his three-week journey.

He dismissed accounts of erratic behavior and reports that he had been using the synthetic drug bath salts. He said he had never used the drug, and said statements that he had were part of an elaborate prank.

Investigators said that McAfee was not a suspect in the death of the former developer, who was found shot in the head in his house on the resort island of San Pedro, but that they wanted to question him.

McAfee told ABC News that the poisoning death of his dogs and the murder just hours later of Faull, who had complained about his dogs, was a coincidence.

McAfee has been hiding from police ever since Faull's death -- but Telesforo Guerra, McAfee's lawyer in Guatemala, said the tactic was born out of necessity, not guilt.

"You don't have to believe what the police say," Guerra told ABC News. "Even though they say he is not a suspect they were trying to capture him."

Guerra, who is a former attorney general of Guatemala, said it would take two to three weeks to secure asylum for his client.

According to McAfee, Guerra is also the uncle of McAfee's 20-year-old girlfriend, Samantha. McAfee said the government raided his beachfront home and threatened Samantha's family.

"Fifteen armed soldiers come in and personally kidnap my housekeeper, threaten Sam's father with torture and haul away half a million dollars of my s***," claimed McAfee. "If they're not after me, then why all these raids? There've been eight raids!"

Before his arrest, McAfee said he would hold a press conference on Thursday in Guatemala City to announce his asylum bid. He has offered to answer questions from Belizean law enforcement over the phone, and denied any involvement in Faull's death.

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Egypt's Mursi back at palace after night of protests

CAIRO (Reuters) - Egyptian President Mohamed Mursi returned to work in Cairo on Wednesday, although scores of protesters angered by his drive to push through a new constitution were still blocking one gate of the presidential palace.

The Islamist leader left the palace in the northern Cairo district of Heliopolis on Tuesday evening as tens of thousands of demonstrators surged around it, clashing briefly with police.

A presidential source said Mursi was back at work in the palace, even though up to 200 demonstrators had camped out near one entrance overnight. Traffic was flowing normally in the area where up to 10,000 people had protested the night before, and riot police had been withdrawn, a Reuters witness said.

The rest of the Egyptian capital was calm, despite the political furor over Mursi's November 22 decree handing himself wide powers and shielding his decisions from judicial oversight.

The Islamist leader says he acted to prevent courts from derailing a newly drafted constitution that will go to a referendum on December 15, after which Mursi's decree will lapse.

The Health Ministry said 18 people had been wounded in the clashes on Tuesday. While they fired tear gas when protesters broke through barricades to reach the palace walls, riot police appeared to handle the disturbance with restraint.

"Our demands from the president: retract the presidential decree and cancel the referendum on the constitution," read a placard hung by demonstrators on a palace gate.

The crowds had gathered in what organizers had dubbed a "last warning" to Mursi. "The people want the downfall of the regime," they chanted, roaring the signature slogan of last year's uprising that toppled President Hosni Mubarak.

But the "last warning" may turn out to be one of the last gasps for a disparate opposition which has little chance of stopping next week's vote on a constitution drafted over six months and swiftly approved by an Islamist-dominated assembly.

Facing the gravest crisis of his six-month-old tenure, the Islamist president has shown no sign of buckling under pressure, confident that the Muslim Brotherhood and its Islamist allies can win the referendum and a parliamentary poll to follow.

(Additional reporting by Tom Perry; Writing by Alistair Lyon; Editing by Janet Lawrence)

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Woman arrested over 160 dogs living in own waste

TOKYO: A woman who kept 160 starving dogs in her house among tonnes of their own waste has been arrested by Japanese police, an official said Wednesday.

Ten tonnes of animal waste and other rubbish were removed from Noriko Ishii's house after the dogs were taken away, he said.

One Bernese Mountain Dog kept by Ishii, 43, weighed just seven kilograms (15 pounds) -- a sixth of what it should have, said the official in Osaka, adding all the animals were "very scrawny".

Jobless Ishii could face a fine of up to 500,000 yen (US$6,000) if convicted under Japan's animal protection laws.

- AFP/ck

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Government deliberately disrupting Rajya Sabha: Arun Jaitley

NEW DELHI: The government and the parties that support it were intentionally disrupting the Rajya Sabha as it lacked the numbers for a vote on the issue of foreign investment in retail, Bharatiya Janata Party (BJP) leader Arun Jaitley said on Wednesday.

"Since the very first day, the government doesn't seem to be serious about conduct of business, specially in Rajya Sabha," the leader of opposition in the Rajya Sabha told reporters after the house was adjourned for the day.

The opposition, he said, doubted if the ruling party and its supporters would allow the debate on foreign direct investment (FDI) to take place Thursday as scheduled.

"I have the suspicion that the government is unsure which way the Rajya Sabha will vote, so it is not letting the house function. We doubt they will allow the debate on FDI tomorrow (Thursday)," he said.

He said a complaint has been made to the chair of the upper house and an explanation sought from Leader of the House, Prime Minister Manmohan Singh.

"The government is deliberately trying to create an atmosphere that the house cannot function. Even when Lok Sabha is functioning normally, Rajya Sabha is being stalled. The whole nation is watching, not a single opposition member has trooped in the well of the house, it is government members and supporting parties that are stalling the house," he said.

The Rajya Sabha was adjourned Wednesday first due to the Bahujan Samaj Party (BSP), which took up the issue of a memorial for B.R. Ambedkar in Mumbai. At noon, after BSP members were pacified, it was the turn of Samajwadi Party (SP) members to gather near the chairman's podium, shouting slogans against reservations in promotions.

Both parties prop the UPA government from outside.

The debate on FDI in retail is scheduled to start in the upper house on Thursday.

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Study: Drug coverage to vary under health law

WASHINGTON (AP) — A new study says basic prescription drug coverage could vary dramatically from state to state under President Barack Obama's health care overhaul.

That's because states get to set benefits for private health plans that will be offered starting in 2014 through new insurance exchanges.

The study out Tuesday from the market analysis firm Avalere Health found that some states will require coverage of virtually all FDA-approved drugs, while others will only require coverage of about half of medications.

Consumers will still have access to essential medications, but some may not have as much choice.

Connecticut, Virginia and Arizona will be among the states with the most generous coverage, while California, Minnesota and North Carolina will be among states with the most limited.

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Avalere Health: http://tinyurl.com/d3b3hfv

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Subway Push Murder Suspect Implicated Self: Police

A suspect believed to be responsible for throwing a man into the path of an oncoming New York City subway train who was taken into custody today has made statements implicating himself, police said.

According to Deputy Commissioner for Public Information Paul Browne, the suspect has been questioned by police since at least early afternoon and while the suspect is in police custody, he has not been officially charged.

Police are continuing to question the suspect and more lineups have been scheduled for tomorrow, Browne said.

Police have not released the suspect's name but began questioning him Tuesday afternoon about the death of Ki-Suck Han, 58, of Queens, N.Y.

Han was tossed onto the subway track at 49th Street and Seventh Avenue around 12:30 p.m. Monday after Han confronted a mumbling man who was alarming other passengers on the train platform. Han tried to scramble back onto the platform, but was crushed by an oncoming train.

The suspect fled the station, prompting a police dragnet for a man described by witnesses and see on surveillance video as a 6-foot-tall, 200-pound black man wearing dreadlocks in his hair.

Witnesses tried to revive the victim after he was hit and provided descriptions of the suspect to police.

Dr. Laura Kaplan, medical resident at Beth Israel Medical Center who was standing on the platform during the incident rushed to give Han aid after he was hit, she said in a statement released by her medical practice today.

New York Police Department

Bystanders Pull Mom, Son From Subway Tracks Watch Video

"A security guard and I performed 3-4 minutes of chest compressions. I hope the family may find some comfort in knowing about the kindness of these good Samaritans, as they endure this terrible loss," Kaplan said.

"I would like the family to know that many people in the station tried to help Mr. Han by alerting the subway personnel," she said.

Kaplan said she wanted to console the family of Han, who she called "a brave man trying to protect other passengers that he did not know."

The suspect had reportedly been mumbling to himself and disturbing other passengers, according to ABC News affiliate WABC. Police told WABC that the suspect could be mentally disturbed.

The suspect could be heard arguing with Han just moments before he hurled Han onto the track bed, according to surveillance video released by the police. The suspect is heard telling the victim to stand in line and "wait for the R train."

A freelance photographer for the New York Post was on the platform and said he ran towards the train flashing his camera hoping to alert the train to stop in time, but the train caught Han against the shoulder deep platform wall.

The photographer, R. Umar Abbasi, caught an eerie photo of Han with his head and arms above the platform and staring at the oncoming train.

Han was treated by EMS workers on the platform for traumatic arrest and rushed to Roosevelt Hospital, where he was pronounced dead, according to the Fire Department of New York.

"I just heard people yelling. The train came to an abrupt stop about three-quarters into the station and that's when I heard a man was hit by a train," Patrick Gomez told ABC News affiliate WABC.

Police set up a command post outside the train station Monday night searching nearby surveillance cameras to try and get a clear image of the suspect, reports WABC. They said Tuesday that the investigation is ongoing.

Anyone with information is asked to call Crime Stoppers at 1-800-577-TIPS (8477). The public can also submit tips by logging onto the Crime Stoppers website at www.nypdcrimestoppers.com or by texting their tips to 274637 (CRIMES) then enter TIP577. All calls are strictly confidential.

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Israel says will stick with settlement plan despite condemnation

JERUSALEM (Reuters) - Israel rejected concerted criticism from the United States and Europe on Monday over Prime Minister Benjamin Netanyahu's decision to expand settlement building after the United Nations' de facto recognition of Palestinian statehood.

Washington urged Israel to reconsider its plan to erect 3,000 more homes in the occupied West Bank and East Jerusalem, saying the move hindered peace efforts with the Palestinians.

Britain, France, Spain, Sweden and Denmark summoned the Israeli ambassadors in their capitals to give similar messages.

An official in Netanyahu's office said Israel would not bend. "Israel will continue to stand by its vital interests, even in the face of international pressure, and there will be no change in the decision that was made," the official said.

Angered by the U.N. General Assembly's upgrading on Thursday of the Palestinians' status in the world body from "observer entity" to "non-member state", Israel said the next day it would build the new dwellings for settlers.

Such projects, on land Israel captured in a 1967 war, are considered illegal by most world powers and have routinely drawn condemnation from them. Approximately 500,000 Israelis and 2.5 million Palestinians live in the two areas.

In a shift that raised the alarm among Palestinians and in world capitals, Netanyahu's pro-settler government also ordered "preliminary zoning and planning work" for thousands of housing units in areas including the "E1" zone east of Jerusalem.

Such construction in the barren hills of E1 has never been put into motion in the face of opposition from Israel's main ally, the United States. Building in the area could bisect the West Bank, cut off Palestinians from Jerusalem and further dim their hopes for a contiguous state.

Israeli television stations reported Jerusalem's district planning commission would soon approve plans for several thousand more housing units, including more than 1,000 Israel had shelved two years ago after angering Washington by publishing the plans before a visit by Vice President Joe Biden.

The settlement plan, U.N. Secretary-General Ban Ki-moon said, would deal "an almost fatal blow" to a two-state solution to the Israeli-Palestinian conflict.

French President Francois Hollande said he was "extremely concerned" and Washington made clear it would not back such Israeli retaliation over the U.N. vote, sought by Palestinians after peace talks collapsed in 2010 over settlement building.

"We urge Israeli leaders to reconsider these unilateral decisions and exercise restraint as these actions are counterproductive and make it harder to resume direct negotiations to achieve a two state solution," White House spokesman Jay Carney told a briefing.

Ahead of a Netanyahu visit this week, Germany, considered Israel's closest ally in Europe, urged it to refrain from expanding settlements, and Russia said it viewed the Israeli moves with serious concern.

RETALIATION

Israeli Finance Minister Yuval Steinitz said Israel could not have remained indifferent to the Palestinians' unilateral move at the United Nations.

"I want to tell you that those same Europeans and Americans who are now telling us 'naughty, naughty' over our response, understand full-well that we have to respond, and they themselves warned the Palestinian Authority," he said.

Palestinian chief negotiator Saeb Erekat said building in E1 "destroys the two-state solution, (establishing) East Jerusalem as the capital of Palestine and practically ends the peace process and any opportunity to talk about negotiations in the future".

The United States, one of the eight countries to vote alongside Israel against the Palestinian resolution at the General Assembly, has said both were counterproductive to the resumption of direct peace talks.

In Europe, only the Czech Republic voted against the status upgrade while many countries, including France, backed it. Netanyahu plans to visit Prague this week to express his thanks.

In the Gaza Strip, Sami Abu Zuhri, spokesman for the governing Hamas Islamist movement, called the settlements "an insult to the international community, which should bear responsibility for Israeli violations and attacks on Palestinians".

Israeli police arrested three Jewish settlers on Monday whom they suspect of arson and other crimes against Palestinian property in the West Bank, including the torching of a car.

Attackers have often proclaimed they are exacting a "price tag" for steps taken against the settler movement by Palestinians, or by the Israeli government.

Alongside the settlement plans, Israel announced it would withhold about $100 million in Palestinian tax revenues from the Palestinian Authority, which exercises limited self-rule in the West Bank, saying Palestinians owed $200 million to Israeli firms.

"These are not steps towards peace, these are steps towards the extension of the conflict," Spanish Foreign Minister Jose Manuel Garcia-Margallo said.

Only three weeks ago, Netanyahu won strong European and U.S. support for a Gaza offensive that Israel said was aimed at curbing persistent cross-border rocket fire.

Favored by opinion polls to win a January 22 national election, he brushed off the condemnation and complaints at home that he is deepening Israel's diplomatic isolation.

Netanyahu told his cabinet on Sunday that his government "will carry on building in Jerusalem and in all the places on the map of Israel's strategic interests".

But while his housing minister has said the government would soon invite bids from contractors to build 1,000 homes for Israelis in East Jerusalem and more than 1,000 in West Bank settlement blocs, the E1 plan is still in its planning stages.

"No one will build until it is clear what will be done there," the minister, Ariel Attias, said on Sunday.

Israel froze much of its activities in E1 under pressure from former U.S. President George W. Bush, and the area has been under the scrutiny of his successor, Barack Obama.

Israel cites historical and Biblical links to the West Bank and Jerusalem and regards all of the holy city as its capital, a claim that is not recognized internationally.

(Additional reporting by Crispian Balmer, Dan Williams, Nidal al-Mughrabi in Gaza, Jihan Abdalla in Ramallah, Steve Gutterman in Moscow, Gareth Jones in Berlin, John Irish and Elizabeth Pineau in Paris and Tim Castle in London; writing by Jeffrey Heller; editing by Philippa Fletcher)

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Islamic finance to surpass trillion-dollar mark in 2012: Tharman

JOHOR BAHRU: Islamic finance is poised to expand over the next 10 to 15 years after surpassing the trillion-dollar mark in 2012, said Minister for Finance Tharman Shanmugaratnam at the World Islamic Economic Forum in Johor Bahru, Malaysia.

Mr Tharman, who is also Singapore's Deputy Prime Minister, said that he was optimistic about the potential for the sector after it chalked-up growth of about 19 per cent a year since 2006.

This has lifted total Shariah-compliant assets to nearly US$1.3 trillion in 2012.

However there is considerable scope for development since Islamic finance now forms less than 1 per cent of the global financial industry, said Mr Tharman.

Even in Muslim countries, Islamic finance constitutes less than 5 per cent of their financial sector, he added.

The minister also noted that Islamic financial institutions have mainly escaped significant damage from the global financial crisis.

"They are well-placed to grow at a time when many of the global banks, especially the European banks, are deleveraging or focusing on consolidating their balance sheets," said Mr Tharman.

He adds that Islamic finance has the potential to diversify into new growth areas such as trade and infrastructure financing in Asia and emerging markets.

This will allow Islamic banks to reduce their exposure to the real estate sector and take advantage of the stronger growth potential of the emerging market economies.

Another factor that can boost the growth potential of Islamic finance is its focus on transparency, price certainty and the risk-sharing framework.

Mr Tharman says Islamic finance can ride this wave of demand for simpler and more basic investments.

Yet, he also pointed out several challenges in the industry that need to be overcome to ensure continued growth.

Among them is the need to reduce fragmentation in Islamic finance markets due to differences in accepted standards of Shariah compliance.

"This has hampered the flow of liquidity between jurisdictions and is in part why there are presently no Islamic equivalents to the international monetary and bond markets."

The minister also touched on the need to manage capital flows in Asia and emerging market economies.

Excessive capital inflows can cause volatility, and it would be "wise to strengthen our policy toolkits in Asia, so that we can deal with unpredictable and often excessive capital flows," said Mr Tharman.

One of the policy responses should be included in a policy maker's toolkit is to curtail volatility in the exchange rate in the short term, he said.

Mr Tharman also pointed to macro-prudential policies such as property cooling measures to discourage speculative demand for residential properties.

"These targeted administrative and prudential measures are not conventional macroeconomic tools. But they are likely to remain part of our policy toolkit, at least for the foreseeable future."

The Finance Minister has also called for greater depth in Asia's capital markets, especially the corporate bond market.

"Broader and deeper capital markets will allow investors to invest for the long term while hedging risks," Mr Tharman said.

- CNA/jc

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Terrorist attacks soar, India among most affected nations: Study

NEW YORK: The number of terrorist attacks each year has more than quadrupled in the decade since September 11, 2001, a study released on Tuesday said, with Iraq, Pakistan and Afghanistan the most affected.

The number of annual deaths in attacks, however, peaked in 2007 -- the height of the Iraq conflict -- and has been falling ever since. The survey reported 7,473 fatalities in 2011, 25 percent down on 2007. That figure included dead suicide bombers and other attackers.

Iraq, Pakistan, Afghanistan, India and Yemen were the five countries most affected by terrorism in descending order, it said, based on a measure giving weightings to number of attacks, fatalities and injuries and level of property damage.

The Global Terrorism Index - published on Tuesday by the US- and Australia-based Institute for Economics and Peace think tank - ranked countries based on data from the Global Terrorism Database run by a consortium based at the University of Maryland, a commonly used reference by security researchers.

The US military interventions pursued as part of the West's anti-al-Qaida "war on terror", the researchers suggested, may have simply made matters worse - while whether they made the US homeland safer was impossible to prove.

Iraqis account for third of terrorism deaths

"After 9/11, terrorist activity fell back to pre-2000 levels until after the Iraq invasion, and has since escalated dramatically," Steve Killelea, founder and executive chairman of the Institute for Economics and Peace, told Reuters in an e-mail interview.

"Iraq accounts for about a third of all terrorist deaths over the last decade, and Iraq, Pakistan and Afghanistan account for over 50 percent of fatalities."

The study says terrorism incidents numbered 982 in 2002, causing 3,823 deaths, rising to 4,564 terrorist incidents globally in 2011, resulting in 7,473 deaths.

The researchers used the University of Maryland definition of "terrorism": "the threatened or actual use of illegal force and violence by a non-state actor to attain a political, economic, religious, or social goal through fear, coercion, or intimidation".

It did not include casualties from government-backed action such as aerial bombing or other killings.

The study said its methodology allowed researchers the scope to exclude actions that could be seen as insurgency, hate crime or organised crime and incidents about which insufficient information was available.

The upswing in attacks in both Afghanistan and Pakistan only occurred after the Iraq war, the study showed, coming at largely the same time as heightened US-backed military campaigns there by NATO and the Pakistani government respectively.

Syria, Yemen worsening

The findings suggested foreign powers should think twice before intervening militarily, Killelea said, even in countries such as Syria, already seeing widespread bloodshed. Unless the conflict was brought to a swift end, terror attacks might actually increase, he said.

The greatest deterioration in 2011 took place in Syria and Yemen, the report said. Yemen has seen a dramatic upsurge in al Qaeda-linked activity in recent years, while Syrian rebels fighting President Bashar al-Assad have increasingly turned to suicide attacks and bombings.

Of the 158 countries surveyed, only 31 had not experienced a single event classified as a "terrorist act" since 2001, the report said. Even when the 9/11 attacks on New York and Washington were taken into account, North America remained the least-affected region over the period studied.

Western Europeans were 19 times more likely to die in a terrorist attack than North Americans, the report said. Aside from the United States - whose rating improved sharply over the decade as the casualties of 2001 were no longer factored in - the greatest improvements were seen in Algeria and Colombia.

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